Sam and Dean work undercover at a spa to investigate murders in which the victims were hundreds of pounds lighter after their deaths. All of the victims attended the spa for weight loss; and the brothers suspect that witches are to blame.
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Sam and Dean investigate a girl's death that may be linked to a ghost. Their probe leads them to encounter Harry and Ed, two famous supernaturalists, who are also on the case.
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Sam and Dean get help from a former member of the Men of Letters to locate the First Blade, after Crowley falls off the wagon and starts injecting himself with human blood.
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Tessa the reaper returns and leads a conspiracy against Castiel's angel followers. Meanwhile, Dean is eager to use the First Blade when the angels are attacked, but Sam worries about the cost to his brother whenever he uses it.
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